Bruce D Gelb Selected Research

Pycnodysostosis

3/2009	Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates.
6/2006	Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass.
4/2004	Decreased bone turnover and deterioration of bone structure in two cases of pycnodysostosis.
8/2002	Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate.

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Bruce D Gelb Research Topics

Disease

24	Noonan Syndrome (Female Pseudo-Turner Syndrome) 01/2020 - 10/2002
8	Congenital Heart Defects (Congenital Heart Defect) 01/2021 - 03/2004
7	LEOPARD Syndrome (Syndrome, LEOPARD) 04/2015 - 02/2006
6	Neoplasms (Cancer) 01/2020 - 04/2009
4	Marfan Syndrome (Marfan's Syndrome) 01/2020 - 05/2013
4	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 04/2018 - 03/2011
4	Pycnodysostosis 03/2009 - 08/2002
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 01/2014
3	Heart Failure 04/2018 - 06/2014
3	Cardiomegaly (Heart Hypertrophy) 04/2015 - 03/2011
3	Deafness (Deaf Mutism) 06/2010 - 11/2002
2	Plexiform Neurofibroma 11/2022 - 01/2020
2	Sarcoma (Soft Tissue Sarcoma) 04/2021 - 09/2012
2	Inflammation (Inflammations) 11/2020 - 07/2020
2	Carcinogenesis 01/2020 - 10/2015
2	Rare Diseases (Rare Disease) 04/2016 - 04/2014
2	Hypertrophy 01/2016 - 07/2011
2	Patent Ductus Arteriosus 04/2015 - 11/2003
2	Osteosclerosis 03/2009 - 04/2004
2	Diabetes Mellitus 02/2004 - 11/2002
2	Megaloblastic Anemia 02/2004 - 11/2002
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 11/2022
1	Heart Diseases (Heart Disease) 01/2022
1	Headache (Headaches) 12/2020
1	Spondylosis 12/2020
1	Migraine Disorders (Migraine) 12/2020
1	Post-Traumatic Headache 12/2020
1	Infections 07/2020
1	Left Ventricular Outflow Obstruction 04/2020
1	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm) 01/2020
1	Necrosis 01/2020
1	Neurodevelopmental Disorders 01/2018
1	Myocarditis (Carditis) 04/2017
1	Atrioventricular Septal Defect 04/2016
1	Lymphoma (Lymphomas) 08/2015
1	Cardiomyopathies (Cardiomyopathy) 07/2015
1	Bicuspid Aortic Valve Disease 04/2015
1	Ventricular Heart Septal Defects (Ventricular Septal Defect) 04/2015
1	Aortic Coarctation 04/2015
1	Double Outlet Right Ventricle 04/2015
1	Aortic Aneurysm (Aneurysm, Aortic) 01/2014
1	Acrocephalosyndactylia (Apert Syndrome) 06/2013
1	Multiple Endocrine Neoplasia Type 2b (MEN 3) 06/2013
1	Aortic Dissection 05/2013
1	Abdominal Aortic Aneurysm 01/2012

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2006
11	Mitogen-Activated Protein KinasesIBA 01/2022 - 10/2006
7	Protein Tyrosine PhosphatasesIBA 08/2012 - 10/2002
5	Cathepsin KIBA 01/2012 - 08/2002
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2022 - 09/2012
3	Monomeric GTP-Binding ProteinsIBA 04/2020 - 01/2018
3	Phosphotransferases (Kinase)IBA 01/2020 - 04/2009
3	Atenolol (Tenormin)FDA LinkGeneric 01/2020 - 05/2013
3	Losartan (Cozaar)FDA LinkGeneric 01/2020 - 05/2013
3	CollagenIBA 04/2016 - 08/2002
2	AZD 6244IBA 11/2022 - 01/2020
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 05/2010
2	CytokinesIBA 11/2020 - 07/2020
2	Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA 01/2020 - 03/2011
2	ChromatinIBA 10/2019 - 01/2018
2	DNA (Deoxyribonucleic Acid)IBA 04/2015 - 03/2004
2	Sirolimus (Rapamycin)FDA Link 04/2015 - 06/2014
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2009 - 03/2004
2	Insulin (Novolin)FDA Link 12/2008 - 11/2002
2	EnzymesIBA 06/2006 - 04/2004
2	Thiamine (Aneurin)FDA Link 02/2004 - 11/2002
1	Bone Morphogenetic Protein 2IBA 01/2021
1	AutoantibodiesIBA 07/2020
1	AntigensIBA 07/2020
1	Protein Kinases (Protein Kinase)IBA 01/2020
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)IBA 01/2020
1	Cytochrome P-450 CYP2C9IBA 01/2020
1	TOR Serine-Threonine KinasesIBA 04/2018
1	diazonaphthalenedisulfonic acid (NDS)IBA 01/2018
1	InterferonsIBA 04/2017
1	SH2 Domain-Containing Protein Tyrosine PhosphatasesIBA 01/2017
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 04/2016
1	RNA (Ribonucleic Acid)IBA 01/2016
1	CalciumIBA 01/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2016
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 11/2015
1	MicroRNAs (MicroRNA)IBA 10/2015
1	Ligases (Synthetase)IBA 08/2015
1	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 04/2015
1	5' Untranslated Regions (5' UTR)IBA 04/2015
1	Brain Natriuretic Peptide (Natrecor)FDA Link 04/2015
1	GTP Phosphohydrolases (GTPases)IBA 08/2014
1	Pharmaceutical PreparationsIBA 04/2014
1	Histones (Histone)IBA 06/2013
1	tyrosine receptor (receptor, tyrosine)IBA 06/2013
1	Cyclin D1IBA 06/2013
1	Codon (Codons)IBA 08/2012
1	Pancreatic Elastase (Elastase)IBA 01/2012
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/2011

Therapy/Procedure

9	Therapeutics 11/2022 - 11/2003
1	Injections 12/2020
1	Art Therapy 01/2020
1	Mechanical Ventilators (Ventilator) 01/2020
1	Palliative Care (Palliative Therapy) 04/2015